(±) 16-HETE

• Target:

  Others|||ATPase

• Related Pathways:

  Others|||Membrane transporter/Ion channel

• Bioactivity:

  Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±) 16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16 (R) -HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16 (S) -HETE does not affect perfusion pressure. At a concentration of 2 ?M the (S) -enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R) -isomer has negligible effects on ATPase activity.

• Smiles:

  CCCCC(O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

• Molecular Formula:

  C20H32O3

• Molecular Weight:

  320.473

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  128914-46-5