(±) 16-HETE

CAT: 0931-T35465-01Size: 25 µgDry Ice: NoHazardous: No
CAT#:0931-T35465-01Size:25 µg
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CAS Number
128914-46-5
Target
Others|||ATPase
Related Pathways
Others|||Membrane transporter/Ion channel
Bioactivity
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±) 16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16 (R) -HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16 (S) -HETE does not affect perfusion pressure. At a concentration of 2 ?M the (S) -enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R) -isomer has negligible effects on ATPase activity.
Smiles
CCCCC(O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.473
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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