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12-HETE

CAT: 804-HY-113439-01Size: 50 μg (312.04 μM x 0.5 mL in Ethanol)Dry Ice: NoHazardous: No
50 μg (312.04 μM x 0.5 mL in Ethanol)Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].
CAS Number
[71030-37-0]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/12-hete.html
Concentration
312.04 μM * 1 mL in Ethanol
Purity
95.70
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\CC(O)/C=C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H32O3
Molecular Weight
320.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838.|[2]Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40.|[3]Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22 (1) :257-64.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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