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Simvastatin hydroxy acid (sodium)

CAT: 0804-HY-115292-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115292-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
CAS Number
101314-97-0
Product Name Alternative
Tenivastatin (sodium) ; Simvastatin Impurity A (sodium)
UNSPSC
12352211
Hazard Statement
H303, H361
Target
HMG-CoA Reductase (HMGCR) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/simvastatin-sodium.html
Concentration
10mM
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCC(C)(C)C(O[C@@H]1[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O[Na])=O)=C[C@H](C)C1)=O
Molecular Formula
C25H39NaO6
Molecular Weight
458.56
Precautions
H303, H361
References & Citations
[1]Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015) . Expert Opin Ther Pat. 2016 Nov;26 (11) :1257-1272.|[2]Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45 (Pt 1) :158-165.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched

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