Products for Research Use Only
RegisterLogin

IK-862

CAT: 0804-HY-118734-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-118734-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
IK-862 is a selective inhibitor of TACE[1].
CAS Number
478911-60-3
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ik-862.html
Solubility
10 mM in DMSO
Smiles
C[C@]1(C2=CC=C(C=C2)OCC3=CC(C)=NC4=C3C=CC=C4)C(N(CC1)[C@H](C)C(NO)=O)=O
Molecular Formula
C25H27N3O4
Molecular Weight
433.50
References & Citations
[1]Georgiadis D, et al. Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008;16 (19) :8781-8794. doi:10.1016/j.bmc.2008.08.058
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(2R)-N-hydroxy-2-[(3S)-3-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]propanamide

(2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide is a hydroxamic acid, a member of quinolines and a member of pyrrolidin-2-ones.

CAS Number478911-60-3
PubChem CID6914621
IUPAC Name(2R)-N-hydroxy-2-[(3S)-3-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]propanamide
Molecular FormulaC25H27N3O4
Molecular Weight433.5
XLogP3.2
Topological Polar Surface Area91.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity680
SMILES
CC1=NC2=CC=CC=C2C(=C1)COC3=CC=C(C=C3)[C@@]4(CCN(C4=O)[C@H](C)C(=O)NO)C
InChI
InChI=1S/C25H27N3O4/c1-16-14-18(21-6-4-5-7-22(21)26-16)15-32-20-10-8-19(9-11-20)25(3)12-13-28(24(25)30)17(2)23(29)27-31/h4-11,14,17,31H,12-13,15H2,1-3H3,(H,27,29)/t17-,25+/m1/s1
InChIKey
YDMIPBHQKFOFQW-NSYGIPOTSA-N
Chemical Structure
2D Structure
2D structure of (2R)-N-hydroxy-2-[(3S)-3-methyl-3-[4-[(2-methylquinolin-4-yl)methoxy]phenyl]-2-oxopyrrolidin-1-yl]propanamide
CAS: 478911-60-3
CID: 6914621
Formula: C25H27N3O4
MW: 433.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight433.5
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass433.20015635
Monoisotopic Mass433.20015635
Topological Polar Surface Area91.8 Ų
Heavy Atom Count32
Formal Charge0
Complexity680
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-W999691CRBN ligand-862
HY-153585-01IK-930
HY-141609-01IK-175
HY-RS16766Ik Mouse Pre-designed siRNA Set A
HY-RS06656IK Human Pre-designed siRNA Set A
HY-RS23206Ik Rat Pre-designed siRNA Set A
HY-118271GNF-8625
HY-102067-013289-8625
HY-131706A-01GNF-8625 monopyridin-N-piperazine (hydrochloride)

Alternative Products

CatalogName
BUP07930-01IK-862
GTR19275575-01CRBN ligand-862
CSB-CL613381HUIK
8B0936-AATGluR4 (Ab-862) Antibody
E3428-75C-01Epothilone D (KOS 862)
C18037-01IK Antibody
GTR19243612-01IK-930
496916ZNF862 (Zinc Finger Protein 862)
343897-01IK discontinued

Popular Products