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LU-32-176B

CAT: 0804-HY-118207Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118207Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LU-32-176B, a GABA transporter 1 (GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].
CAS Number
770688-66-9
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lu-32-176b.html
Solubility
10 mM in DMSO
Smiles
OC1=NOC2=C1C(CCC2)NCCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Molecular Formula
C23H24F2N2O2
Molecular Weight
398.45
References & Citations
[1]Schousboe A, et al. GABA transporters as drug targets for modulation of GABAergic activity. Biochem Pharmacol. 2004;68 (8) :1557-1563.|[2]White HS, et al. First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther. 2005;312 (2) :866-874.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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