LU-005i

• UNSPSC Description:

  LU-005i is a potent inhibitor of β5i subunit of immunoproteasomes (IC50 = 6.6 nM), selective over β5c subunit (IC50 = 287 nM)[1].

• Target Antigen:

  Proteasome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/lu-005i.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  COC(C=C1)=CC=C1C[C@H](NC([C@H](C)NC(CN2CCOCC2)=O)=O)C(N[C@@H](CC3CCCCC3)C([C@]4(CO4)C)=O)=O

• Molecular Weight:

  586.72

• References & Citations:

  [1]Rezvan Moallemian, et al. Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation.Biochem Pharmacol. 2020 Jul:177:113964.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  1620107-33-6