Lu AE51090

• Description :

  Lu AE51090 is selective muscarinic M1 receptor agonist with blood-brain barrier penetration. Lu AE51090 activates human M1 receptor with EC50 of 61 nM, while showing no significant agonism at M2-M5 receptors. Lu AE51090 exerts procognitive effects in mice. Lu AE51090 can be used for the study of Alzheimer’s disease (AD) and cognitive impairment associated with schizophrenia (CIAS) [1].

• UNSPSC :

  12352005

• Target :

  MAChR

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Purity :

  99.51

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1CCN(CCCN2C3=CC=CC=C3OCC2=O)CC1)CC4=CC=CC=C4

• Molecular Formula :

  C24H29N3O3

• Molecular Weight :

  407.51

• References & Citations :

  [1]Sams AG, et al. Discovery of N-{1-[3- (3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl) propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090) : an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. J Med Chem. 2010 Sep 9;53 (17) :6386-97.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAChR1; mAChR2; mAChR3; mAChR4; mAChR5

• CAS Number :

  [1186229-95-7]