Lu AA47070

• Description :

  Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/lu-aa47070.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=P(O)(O)OCN1C=CS/C1=N\C(C2=CC(F)=C(NC(CC(C)(C)C)=O)C(F)=C2)=O

• Molecular Formula :

  C17H20F2N3O6PS

• Molecular Weight :

  463.39

• References & Citations :

  [1]Discovery of Phosphoric Acid Mono-{2-[ (E/Z) -4- (3,3-dimethyl-butyrylamino) -3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070) : A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor Antagonist J. Med. Chem., Article ASAP DOI: 10.1021/jm1008659 Publication Date (Web) : January 6, 2011|[2]Collins LE, et al. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100 (3) :498-505.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [913842-25-8]