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Lu AF58786

CAT: 0804-HY-180320Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-180320Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lu AF58786 is a potent and selective LRRK2 inhibitor with an IC50 of 12 nM. Lu AF58786 also exhibits inhibition activity against LRRK2 G2019S and LRRK2 A2016T with IC50s of 19 and 93 nM. Lu AF58786 inhibits phosphorylation of LRRK2, Rab10 and Rab12 in human peripheral blood mononuclear cells. Lu AF58786 can be used for parkinson’s disease research[1][2].
CAS Number
[1632368-13-8]
UNSPSC
12352005
Target
LRRK2
Related Pathways
Autophagy
Field of Research
Neurological Disease
Smiles
N#CC1=CNC2=NC(NC3=NN(C)C=C3)=CC(C4=CC(C)=CC=C4)=C12
Molecular Formula
C19H16N6
Molecular Weight
328.37
References & Citations
[1]Thirstrup K, et al. Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells. Sci Rep. 2017 Aug 31;7 (1) :10300.|[2]Williamson DS, et al. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1) . J Med Chem. 2017 Nov 9;60 (21) :8945-8962.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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