MDL 101146

• Description:

  MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].

• UNSPSC:

  12352005

• Target:

  Elastase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mdl-101146.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (N (CCC1) [C@@H]1C (NC (C (C) C) C (C (F) (F) C (F) (F) F) =O) =O) [C@H] (C (C) C) NC (C (C=C2) =CC=C2C (N3CCOCC3) =O) =O

• Molecular Formula:

  C29H37F5N4O6

• Molecular Weight:

  632.62

• References & Citations:

  [1]Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl|[2]M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46 (12) :503-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  149859-17-6