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MDL 101146

CAT: 0804-HY-117668Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117668Size:1 Each
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Description
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2].
CAS Number
[149859-17-6]
UNSPSC
12352005
Target
Elastase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mdl-101146.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CCC1)[C@@H]1C(NC(C(C)C)C(C(F)(F)C(F)(F)F)=O)=O)[C@H](C(C)C)NC(C(C=C2)=CC=C2C(N3CCOCC3)=O)=O
Molecular Formula
C29H37F5N4O6
Molecular Weight
632.62
References & Citations
[1]Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl|[2]M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46 (12) :503-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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