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AChE-IN-11

CAT: 0804-HY-115973Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115973Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-11 (compound 5C) is a triple inhibitor targeting AChE/MAO-B/BACE1 (IC50=7.9 μM, 9.9 μM, 8.3 μM, respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease[1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-11.html
Solubility
10 mM in DMSO
Smiles
[H][C@@](COC1=CC(O)=C(C=C1)C(C)=O)(CN2CCN(CC2)C(C)C)O
Molecular Formula
C18H28N2O4
Molecular Weight
336.43
References & Citations
[1]Gaofeng Zhu, et al. Development of novel 2-acetylphenol-O-alkylhydroxyethylamine derivatives as multifunctional agents for Alzheimer’s disease treatment.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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