FLT3/CDK4-IN-1

FLT3/CDK4-IN-1

• CAS Number: 2762296-44-4
• UNSPSC Description: FLT3/CDK4-IN-1 is a potent, high selective and orally active FLT3/CDK4 dual inhibitor (IC50=11 and 7 nM for FLT3 and CDK4, respectively). FLT3/CDK4-IN-1 has antiproliferative activities against certain cancer cells. FLT3/CDK4-IN-1 has good antitumor effect in vivo[1].
• Target Antigen: CDK; FLT3
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/flt3-cdk4-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC(N1N=CC2=NC=C(C3=NC(NC4=CC=C(N5CCN(CC)CC5)C(F)=C4)=NC=C3F)C=C21)C
• Molecular Weight: 478.54
• References & Citations: [1]Li X, et al. Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors. Bioorg Chem. 2022;121:105669.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported