CDK4-IN-1

CDK4-IN-1

• CAS Number: 1256963-02-6
• UNSPSC Description: CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively. IC50 Value: 10 nM (CDK4/Cyclin D1) [1] Target: CDK4 CDK4/6 inhibitor imposed a G1 block on cells at 0.37μM in the CDK4 Cellular Assays. CDK4/6 inhibitor exhibited the most sustained G1 arrest among five compounds and were tested further against a selection of serine-threonine and tyrosine kinases and proved to be selective for CDK4/6 over 35 other kinases [1].
• Target Antigen: CDK
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk4-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CN(C1CCN(C2=CN=C(NC3=NC=CC(C4=C(Cl)NN=C4C(C)C)=N3)C=C2)CC1)C
• Molecular Weight: 440.97
• References & Citations: [1]Cho YS, et al. 4-(Pyrazol-4-yl)-pyrimidines as selective inhibitors of cyclin-dependent kinase 4/6. J Med Chem. 2010 Nov 25;53(22):7938-57.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported