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PptT-IN-1

CAT: 0804-HY-115882Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115882Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PptT-IN-1 (compound 5j) is a potent inhibitor of with phosphopantetheinyl phosphoryl transferase (PptT) an IC50 of 2.8 μM. Phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. PptT-IN-1 has the potential for the research of tuberculosis[1].
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pptt-in-1.html
Solubility
10 mM in DMSO
Smiles
CCNC(NC(NC1=C(C=C(C=C1CC)C(NC(C)C)=O)CC)=O)=N
Molecular Formula
C18H29N5O2
Molecular Weight
347.46
References & Citations
[1]Ottavi S, et al. In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. J Med Chem. 2022 Feb 10;65 (3) :1996-2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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