Products for Research Use Only
RegisterLogin

PPTN (hydrochloride)

CAT: 0804-HY-110322-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-110322-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity[1].
CAS Number
1992047-65-0
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pptn-hydrochloride.html
Purity
99.89
Solubility
DMSO : 66.67 mg/mL (adjust pH to 11 with 1 M NaOH)
Smiles
FC(F)(C1=CC=C(C2=CC=C3C(C4=CC=C(C=C4)C5CCNCC5)=CC(C(O)=O)=CC3=C2)C=C1)F.Cl
Molecular Formula
C29H25ClF3NO2
Molecular Weight
511.96
References & Citations
[1]Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84 (1) :41-9.|[2]Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y14 Receptor
Citation 01
Clin Immunol. 2024 Jun 29:110300.|Neuropharmacology. 2025 Oct 14:110723.|Cell Rep. 2025 Nov 18;44 (12) :116577.|Int Immunopharmacol. 2023 Jan:114:109507.

Chemical Information

PPTN hydrochloride
CAS Number1992047-65-0
PubChem CID121513852
IUPAC Name4-(4-piperidin-4-ylphenyl)-7-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxylic acid;hydrochloride
Molecular FormulaC29H25ClF3NO2
Molecular Weight512.0
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count36
Formal Charge0
Complexity705
SMILES
C1CNCCC1C2=CC=C(C=C2)C3=C4C=CC(=CC4=CC(=C3)C(=O)O)C5=CC=C(C=C5)C(F)(F)F.Cl
InChI
InChI=1S/C29H24F3NO2.ClH/c30-29(31,32)25-8-5-19(6-9-25)22-7-10-26-23(15-22)16-24(28(34)35)17-27(26)21-3-1-18(2-4-21)20-11-13-33-14-12-20;/h1-10,15-17,20,33H,11-14H2,(H,34,35);1H
InChIKey
FKMVYPCBLWYNAV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PPTN hydrochloride
CAS: 1992047-65-0
CID: 121513852
Formula: C29H25ClF3NO2
MW: 512.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight512.0
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass511.1525912
Monoisotopic Mass511.1525912
Topological Polar Surface Area49.3 Ų
Heavy Atom Count36
Formal Charge0
Complexity705
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-110322A-01PPTN
HY-103055PPTN (mesylate)
HY-B0500BAlverine (hydrochloride)
HY-N14912β-Prumycin hydrochloride
HY-N0300A-01Tetrahydropalmatine (hydrochloride)
HY-172541LN6023 (hydrochloride)
HY-172070-01Metaescaline (hydrochloride)
HY-170052-01α-Isopropylaminohexanophenone (hydrochloride)
HY-168824-01Cypenamine (hydrochloride)
HY-161794A-01SP3N (hydrochloride)

Alternative Products

CatalogName
471176PPTN hydrochloride
4862/10PPTN hydrochloride 10 mg
M33073-01PPTN
MBS5774401PPTN Mesylate
P100496PPtn (mouse) -promoter-Fluc
P91771PPtn (mouse) -Fluc-SV40-hRluc-Neo
300563Ligustrazine Hydrochloride (Chuanxiongzine hydrochloride)
D3190-91GDeoxynojirimycin Hydrochloride (DNJ Hydrochloride)
OR1043462-01Hydrochloride
MBS6103001-01O-Cyclopropylmethyl-hydroxylamine, Hydrochloride (Cyclopropylmethoxyamine, Hydrochloride, Cyclopropylmethoxylamine, Hydrochloride)

Popular Products