TWIK-1/TREK-1-IN-1

TWIK-1/TREK-1-IN-1

• CAS Number: 1440532-30-8
• UNSPSC Description: TWIK-1/TREK-1-IN-1 (compound 2a) is an inhibitor of the TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.36 μM and 14.6 μM, respectively, and has antidepressant-like effects[1].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/twik-1-trek-1-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: OC(CC1)(C2=CC=CC=C2)CCN1C[C@@H](O)COC3=CC=C(C(F)(F)F)C=C3
• Molecular Weight: 395.42
• References & Citations: [1]Lee EH, et al. Novel potent blockers for TWIK-1/TREK-1 heterodimers as potential antidepressants. Biomed Pharmacother. 2023 Sep;165:115139.. .
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported