PPTN

• Description:

  PPTN, a chemical probe, is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity[1].

• UNSPSC:

  12352005

• Target:

  P2Y Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pptn.html

• Purity:

  99.63

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic; adjust pH to 7 with 1 M HCL)

• Smiles:

  O=C(O)C1=CC(C2=CC=C(C3CCNCC3)C=C2)=C4C=CC(C5=CC=C(C(F)(F)F)C=C5)=CC4=C1

• Molecular Formula:

  C29H24F3NO2

• Molecular Weight:

  475.50

• References & Citations:

  [1]Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84 (1) :41-9.|[2]Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P2Y14 Receptor

• Citation 01:

  Cell Rep. 2025 Nov 18;44 (12) :116577.|Int Immunopharmacol. 2023 Jan:114:109507.|Clin Immunol. 2024 Jun 29:110300.|Neuropharmacology. 2025 Oct 14:110723.

• CAS Number:

  [1160271-30-6]