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BMS-248360

CAT: 0804-HY-114953Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114953Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor, with Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects[1].
CAS Number
254737-87-6
UNSPSC
12352005
Target
Angiotensin Receptor; Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bms-248360.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC=C1C2=CC=C(CN3C(CCCC)=NC4(CCCC4)C3=O)C=C2CN5C(C(C)(C)CC5)=O)(NC6=C(C)C(C)=NO6)=O
Molecular Formula
C36H45N5O5S
Molecular Weight
659.84
References & Citations
[1]Murugesan N, et al. Discovery of N-isoxazolyl biphenylsulfonamides as potent dual angiotensin II and endothelin A receptor antagonists. J Med Chem. 2002 Aug 29;45 (18) :3829-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor; AT2 Receptor

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