(E/Z) -BIO-acetoxime

• Description:

  (E/Z) -BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z) -BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM) [1].

• Product Name Alternative:

  GSK-​3 Inhibitor X

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  CDK; GSK-3

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/e-z-bio-acetoxime.html

• Purity:

  99.0

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(O/N=C1/C(NC2=C1C=CC=C2)=C3C(NC4=C\3C=CC(Br)=C4)=O)=O

• Molecular Formula:

  C18H12BrN3O3

• Molecular Weight:

  398.21

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK1; CDK2; CDK5; GSK-3α; GSK-3β

• CAS Number:

  740841-15-0