PF-2771

• Description :

  PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor, inhibiting CENP-E motor activity with an IC50 of 16.1 nM; PF-2771 is used as an anticancer agent.

• UNSPSC :

  12352005

• Target :

  Kinesin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PF-2771.html

• Concentration :

  10mM

• Purity :

  99.66

• Solubility :

  DMSO : ≥ 32 mg/mL

• Smiles :

  ClC1=CC(C(N[C@@H](CC2=CC=C(C3=CN(C)C(C(C)=O)=N3)C=C2)CNC(CN(C)C)=O)=O)=CC=C1OC(C)C

• Molecular Formula :

  C29H36ClN5O4

• Molecular Weight :

  554.08

• References & Citations :

  [1]Kung PP, et al. Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer. Mol Cancer Ther. 2014 Aug;13 (8) :2104-15.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Kinesin-7/CENP-E

• CAS Number :

  [2070009-55-9]