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PF-06807656

CAT: 0804-HY-123803Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123803Size:1 Each
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Description
PF-06807656 is a selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor. PF-06807656 has an IC50 of 61 nM against hROMK in patch-clamp assays. PF-06807656 exhibits high selectivity for inhibiting rat ROMK and is insensitive to N171D pore mutations. PF-06807656 may be used in cardiovascular disease research[1].
CAS Number
2213468-04-1
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(NC(C1=NN(C)N=C1)C)C2=CC=C(OC)C(S(=O)(NC3=CC=C(Cl)C=C3)=O)=C2
Molecular Formula
C19H20ClN5O4S
Molecular Weight
449.91
References & Citations
[1]Sammons MF, et al. Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors. ACS Med Chem Lett. 2018 Jan 19;9 (2) :125-130.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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