PF-06807656

• Description:

  PF-06807656 is a selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor. PF-06807656 has an IC50 of 61 nM against hROMK in patch-clamp assays. PF-06807656 exhibits high selectivity for inhibiting rat ROMK and is insensitive to N171D pore mutations. PF-06807656 may be used in cardiovascular disease research[1].

• UNSPSC:

  12352005

• Target:

  Potassium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(NC(C1=NN(C)N=C1)C)C2=CC=C(OC)C(S(=O)(NC3=CC=C(Cl)C=C3)=O)=C2

• Molecular Formula:

  C19H20ClN5O4S

• Molecular Weight:

  449.91

• References & Citations:

  [1]Sammons MF, et al. Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors. ACS Med Chem Lett. 2018 Jan 19;9 (2) :125-130.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2213468-04-1]