PF-05139962

• Description:

  PF-05139962 is a cyclic sulfone mTOR kinase inhibitor. PF-05139962 exhibits potent mTOR (Ki = 5 nM, pS473 IC50 = 48 nM, pS6 IC50 = 6 nM) inhibitory activity and high selectivity[1].

• UNSPSC:

  12352005

• Target:

  MTOR

• Related Pathways:

  PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Smiles:

  O=C(NCC)NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C(CS4(=O)=O)C(CC4)=N2)C=C1

• Molecular Formula:

  C21H27N5O4S

• Molecular Weight:

  445.54

• References & Citations:

  [1] Liu KK, et al. Conformationally-restricted cyclic sulfones as potent and selective mTOR kinase inhibitors. Bioorg Med Chem Lett. 2012 Aug 1;22 (15) :5114-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1393712-18-9]