PF-AKT400

• Description :

  PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM) .

• Product Name Alternative :

  AKT protein kinase inhibitor

• UNSPSC :

  12352005

• Target :

  Akt

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/AKT-inhibitor.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  N[C@@](CC1)(CNC(C2=CC=C(F)C=C2F)=O)CN1C3=C4C(NC=C4CC)=NC=N3

• Molecular Formula :

  C20H22F2N6O

• Molecular Weight :

  400.43

• References & Citations :

  [1]Chen SF, et al. Binding selectivity studies of PKBα using molecular dynamics simulation and free energy calculations. J Mol Model. 2013 Nov;19 (11) :5097-5112.|[2]Freeman-Cook KD, et al. Design of selective, ATP-competitive inhibitors of Akt. J Med Chem. 2010 Jun 24;53 (12) :4615-4622.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Akt1

• CAS Number :

  [1004990-28-6]