Risperidone-d6

CAT: 0804-HY-11018S2-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-11018S2-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018) . Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively[1][2].
CAS Number
[1225444-65-4]
Product Name Alternative
R 64 766-d6
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor; P-glycoprotein
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])(C1=C(C(N2CCCC([2H])(C2=N1)[2H])=O)CCN3CCC(CC3)C4=NOC5=C(C(F)=CC=C45)[2H])[2H]
Molecular Formula
C23H21D6FN4O2
Molecular Weight
416.52
References & Citations
[1]Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl) . 1993;110 (3) :265-72.|[2]Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12 (1) :197-204.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
Phase 4
Isoform
5-HT2 Receptor; D2 Receptor; α-1 microglobulin

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