TC-N 22A

CAT: 0804-HY-18679Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-18679Size:1 mg

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Description

TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1].

CAS Number

1314140-00-5

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tc-n-22a.html

Solubility

10 mM in DMSO

Smiles

C1(NC2=NC3=C(CCCC4=NNC=C43)S2)=CC=CC=N1

Molecular Formula

C14H13N5S

Molecular Weight

283.35

References & Citations

[1]Sang-Phyo Hong, et al. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem. 2011 Jul 28;54 (14) :5070-81.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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B5565-50	TC-N 22A
B5594-10	TC-N 1752
B7639-5	TC 14012
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BA5050-10	TC-2153
CP048-010	TC Gel
T68154-01	TC-2216

TC-N 22A

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