TC-N 22A

TC-N 22A

• CAS Number: 1314140-00-5
• UNSPSC Description: TC-N 22A is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo[1].
• Target Antigen: mGluR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/tc-n-22a.html
• Solubility: 10 mM in DMSO
• Smiles: C1(NC2=NC3=C(CCCC4=NNC=C43)S2)=CC=CC=N1
• Molecular Weight: 283.35
• References & Citations: [1]Sang-Phyo Hong, et al. Tricyclic thiazolopyrazole derivatives as metabotropic glutamate receptor 4 positive allosteric modulators. J Med Chem. 2011 Jul 28;54(14):5070-81.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported