AMG-076

• UNSPSC Description:

  AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice[1].

• Target Antigen:

  MCHR1 (GPR24)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/amg-076.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C1(CCCCC1)CCN2CC[C@@]3(CC4=C([C@@H]([C@]3(C2)[H])C)C(C=C(C=C5)C(F)(F)F)=C5N4)[H].O=S(C6=CC=CC=C6)(O)=O

• Molecular Weight:

  620.72

• References & Citations:

  [1]Alykhan S Motani, et al. Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models. Pharmacol Res Perspect. 2013 Oct;1(1):e00003.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  1001438-96-5