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AT-076

CAT: 0804-HY-106732Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-106732Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AT-076 is an opioid pan antagonist at nociception, kappa, mu, and delta opioid receptors, with Ki values of 1.75 nM (NOP), 1.67 nM (MOP), 1.14 nM (KOP) and 19.6 nM (DOP), respectively[1][2].
CAS Number
1657028-64-2
UNSPSC
12352005
Target
Opioid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/at-076.html
Smiles
OC1=CC=CC(C(CC2)CCN2C[C@H](C(C)C)NC([C@H]3CC4=CC=C(O)C=C4CN3)=O)=C1
Molecular Formula
C26H35N3O3
Molecular Weight
437.57
References & Citations
[1]Nurulain T Zaveri, et al. Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors. ACS Chem Neurosci. 2015 Apr 15;6 (4) :646-57.|[2]V Blair Journigan, et al. Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships. Sci Rep. 2017 Oct 16;7 (1) :13255.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOP Receptor/ORL1; δ Opioid Receptor/DOR; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR

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