AMG-8718

CAT: 0804-HY-12938Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12938Size:1 Each
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Description
AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 μM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ40 levels in the CSF and brain[1].
CAS Number
[1215868-94-2]
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amg-8718.html
Solubility
10 mM in DMSO
Smiles
NC(OC1)=N[C@]1(C2=CC(C#CC3(C)COC3)=CN=C2O4)C5=C4C=CC(C6=CC=CN=C6F)=C5
Molecular Formula
C25H19FN4O3
Molecular Weight
442.44
References & Citations
[1]Dineen TA, et al. Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1) : identification of (S) -7- (2-fluoropyridin-3-yl) -3- ((3-methyloxetan-3-yl) ethynyl) -5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718) . J Med Chem. 2014 Dec 11;57 (23) :9811-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1; BACE2

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