AMG-8718

• Description:

  AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 μM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ40 levels in the CSF and brain[1].

• UNSPSC:

  12352005

• Target:

  Beta-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/amg-8718.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC(OC1)=N[C@]1(C2=CC(C#CC3(C)COC3)=CN=C2O4)C5=C4C=CC(C6=CC=CN=C6F)=C5

• Molecular Formula:

  C25H19FN4O3

• Molecular Weight:

  442.44

• References & Citations:

  [1]Dineen TA, et al. Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1) : identification of (S) -7- (2-fluoropyridin-3-yl) -3- ((3-methyloxetan-3-yl) ethynyl) -5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718) . J Med Chem. 2014 Dec 11;57 (23) :9811-31.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BACE1; BACE2

• CAS Number:

  [1215868-94-2]