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AMG-548

CAT: 0804-HY-108642-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-108642-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG-548, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2].
CAS Number
864249-60-5
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Casein Kinase; p38 MAPK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amg-548.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C)C(NC[C@@H](N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4
Molecular Formula
C29H27N5O
Molecular Weight
461.56
Precautions
H301, H315, H319, H335
References & Citations
[1]Lee MR, et al. MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alphaprotein. Curr Med Chem. 2005;12 (25) :2979-94.|[2]Verkaar F, et al. Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ. Chem Biol. 2011 Apr 22;18 (4) :485-94.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; p38α; p38β; p38γ; p38δ

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Alternative Products

CatalogName
MBS5766035AMG-548
MBS386615-01AMG 548
T63371-01AMG-548 hydrochloride
A10970-25AMG 548 25mg
MBS5752683AMG-548 dihydrochloride
A10970-100AMG 548 100mg
A10970-50AMG 548 50mg
A10970-10AMG 548 10mg
A10970-5AMG 548 5mg
T10298-01AMG-548 hydrochloride (864249-60-5 free base)

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