AMG-548

• Description :

  AMG-548, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε[2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H315, H319, H335

• Target :

  Casein Kinase; p38 MAPK

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/amg-548.html

• Purity :

  99.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1N(C)C(NC[C@@H](N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4

• Molecular Formula :

  C29H27N5O

• Molecular Weight :

  461.56

• Precautions :

  H301, H315, H319, H335

• References & Citations :

  [1]Lee MR, et al. MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38alphaprotein. Curr Med Chem. 2005;12 (25) :2979-94.|[2]Verkaar F, et al. Inhibition of Wnt/β-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Iδ/ɛ. Chem Biol. 2011 Apr 22;18 (4) :485-94.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CK1; p38α; p38β; p38γ; p38δ

• CAS Number :

  [864249-60-5]