Cis VH-298

CAT: 0804-HY-100947A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-100947A-01Size:5 mg
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Description
Cis VH-298 is the cis form of VH-298 (HY-100947) . cis VH-298 results in a significant loss of binding specificity of hydroxylated HIF-1a peptides to VHL in vitro[1].
CAS Number
[2097381-86-5]
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/cis-vh-298.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
References & Citations
[1]Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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MBS3603305-01VH 298
MBS3844772-01VH-298
A20326-100VH-298 100mg
A20326-2VH-298 2mg
A20326-10VH-298 10mg
A20326-25VH-298 25mg
A20326-50VH-298 50mg
A20326-5VH-298 5mg
6156/10VH 298 10 mg
6156/50VH 298 50 mg

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