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VH 101, acid

CAT: 0804-HY-47070-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-47070-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand[1].
CAS Number
2408341-97-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vh-101-acid.html
Purity
98.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(O)=O)=O)=O
Molecular Formula
C28H35FN4O6S
Molecular Weight
574.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Jian Jin, et al. Protein tyrosine kinase 6 (ptk6) degradation / disruption compounds and methods of use. WO2020010204A1.2020-01-09.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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