Products for Research Use Only
RegisterLogin

VH-298 (Standard)

CAT: 0804-HY-100947RSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100947RSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
VH-298 (Standard) is the analytical standard of VH-298. This product is intended for research and analytical applications. VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM. VH-298 leads to HIF-α accumulation inside HeLa cells. VH-298 is an E3 ligase Ligand, and can be used for synthesis of PROTACs[1].
CAS Number
2097381-85-4
Target
HIF/HIF Prolyl-Hydroxylase; Ligands for E3 Ligase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others; PROTAC
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
References & Citations
[1]Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-100947-01VH-298
HY-100947A-01Cis VH-298
HY-101671RS-methyl-KE-298 (Standard)
HY-P10698VH-N412
HY-130249-01BAY-298
HY-47851-01VH 101, thiol
HY-116165-01ML-298
HY-47070-01VH 101, acid
HY-W953127CRBN ligand-298
HY-178924Antibacterial agent 298

Alternative Products

CatalogName
MBS3603305-01VH 298
TQ0121-01VH-298
A20326-50VH-298 50mg
A20326-25VH-298 25mg
A20326-10VH-298 10mg
A20326-2VH-298 2mg
A20326-100VH-298 100mg
A20326-5VH-298 5mg
6156/10VH 298 10 mg
6156/50VH 298 50 mg

Popular Products