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VH-N412

CAT: 0804-HY-P10698Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10698Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VH-N412 is a vectorized neuropeptide (NT) with good blood-brain barrier permeability. VH-N412 binds to the low-density lipoprotein receptor (LDLR) and neuropeptide receptor 1 (NTSR-1), and acts as a pharmacological-induced hypothermia (PIH) inducer. VH-N412 exhibits anticonvulsant and neuroprotective effects, and can be used in the study of neurological diseases such as epilepsy. [1]
CAS Number
1801681-81-1
UNSPSC
12352209
Target
LDLR; Peptide-Drug Conjugates (PDCs)
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vh-n412.html
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)NC([C@H]2N(CCC2)C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CCOCCOCCOCCOCCOCCOCCNC([C@@H]3CSSC[C@H](C(N[C@H](C(N4[C@](CCCC4)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N(CC(N3)=O)C)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)CCSC)=O)NC(CC)=O)=O)=O)=O)=O)=O
Molecular Formula
C94H163N27O24S3
Molecular Weight
2151.66
References & Citations
[1]Ferhat L, et al. A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice[J]. bioRxiv, 2024: 2024.07. 15.603208.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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