VH-298

• CAS Number :

  2097381-85-4

• Target :

  Ligand for E3 Ligase|||HIF/HIF Prolyl-Hydroxylase|||HIF

• Related Pathways :

  Angiogenesis|||PROTAC|||Metabolism|||Chromatin/Epigenetic

• Purity :

  >99.99%

• Bioactivity :

  VH-298 is a potent inhibitor of VHL that stabilizes HIF-? and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-? protein-protein interaction downstream of HIF-? hydroxylation by PHD enzymes.

• Smiles :

  Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)cc1

• Molecular Formula :

  C27H33N5O4S

• Molecular Weight :

  523.65

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C