VH-298

CAT: 0931-MF-0019889-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0019889-01Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2097381-85-4
Target
Ligand for E3 Ligase|||HIF/HIF Prolyl-Hydroxylase|||HIF
Related Pathways
Angiogenesis|||PROTAC|||Metabolism|||Chromatin/Epigenetic
Purity
>99.99%
Bioactivity
VH-298 is a potent inhibitor of VHL that stabilizes HIF-? and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-? protein-protein interaction downstream of HIF-? hydroxylation by PHD enzymes.
Smiles
Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)cc1
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS3603305-01VH 298
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A20326-5VH-298 5mg

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