VH-298

• Target:

  Ligand for E3 Ligase|||HIF/HIF Prolyl-Hydroxylase|||HIF

• Related Pathways:

  Angiogenesis|||PROTAC|||Metabolism|||Chromatin/Epigenetic

• Purity:

  >99.99%

• Bioactivity:

  VH-298 is a potent inhibitor of VHL that stabilizes HIF-? and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-? protein-protein interaction downstream of HIF-? hydroxylation by PHD enzymes.

• Smiles:

  Cc1ncsc1-c1ccc (CNC (=O) [C@@H]2C[C@@H] (O) CN2C (=O) [C@@H] (NC (=O) C2 (CC2) C#N) C (C) (C) C) cc1

• Molecular Formula:

  C27H33N5O4S

• Molecular Weight:

  523.65

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2097381-85-4