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VH-298

CAT: 0804-HY-100947-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100947-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM. VH-298 leads to HIF-α accumulation inside HeLa cells. VH-298 is an E3 ligase Ligand, and can be used for synthesis of PROTACs[1].
CAS Number
2097381-85-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HIF/HIF Prolyl-Hydroxylase; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/VH-298.html
Purity
99.83
Solubility
DMSO : ≥ 83.3 mg/mL
Smiles
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(C2(CC2)C#N)=O)=O)C[C@H](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3
Molecular Formula
C27H33N5O4S
Molecular Weight
523.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

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