MK 436

• Description:

  MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America[1][2].

• Product Name Alternative:

  MK-0436

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/mk-436.html

• Smiles:

  O=[N+] (C1=CN=C (C2=NOC3CCCCC23) N1C) [O-]

• Molecular Formula:

  C11H14N4O3

• Molecular Weight:

  250.25

• References & Citations:

  [1]VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3- (1-methyl-5-nitro-1H-imidazol-2-yl) -1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980) : 1288-1292.|[2]Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983) : 693-698.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  33450-08-7