MK 436

• Description :

  MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America[1][2].

• Product Name Alternative :

  MK-0436

• UNSPSC :

  12352005

• Target :

  Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/mk-436.html

• Smiles :

  O=[N+](C1=CN=C(C2=NOC3CCCCC23)N1C)[O-]

• Molecular Formula :

  C11H14N4O3

• Molecular Weight :

  250.25

• References & Citations :

  [1]VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3- (1-methyl-5-nitro-1H-imidazol-2-yl) -1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980) : 1288-1292.|[2]Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983) : 693-698.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [33450-08-7]