SOF-436

• Description :

  SOF-436 is a KRAS inhibitor that inhibits SOS1-mediated KRAS nucleotide exchange (IC50 = 60 μM) and the binding of KRAS to the effector protein RAF. SOF-436 can be used in cancer research[1].

• UNSPSC :

  12352005

• Target :

  Ras

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Field of Research :

  Cancer

• Smiles :

  O=S(C1=CC(S(F)(=O)=O)=CC=C1)(NC2=CC(F)=C(C3CC3)C=C2)=O

• Molecular Formula :

  C15H13F2NO4S2

• Molecular Weight :

  373.39

• References & Citations :

  [1]Landgraf A, et al. Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation. ChemMedChem. 2025 Mar 18:e202400624.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2224491-20-5]