MRL-436

• Description:

  MRL-436 is a RNA polymerase inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin (HY-B0272) -resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin-resistant strains[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H335

• Target:

  Bacterial; DNA/RNA Synthesis

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Smiles:

  O=C(C1=CC=CN2C1=NN=C2CC(C)C)NC3C4=C(C5=C3C=CC=C5)C=CC=C4

• Molecular Formula:

  C24H22N4O

• Molecular Weight:

  382.46

• Precautions:

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations:

  [1]Walker SS, et al. Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor. ACS Chem Biol. 2017 May 19;12 (5) :1346-1352.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2095432-38-3]