RTx-152

• Description :

  RTx-152 traps Polθ on DNA and is an allosteric Polθ-pol inhibitor (IC50: 6.2 nM) . RTx-152 selectively kills HR-deficient cancer cells, and suppresses PARP inhibitor resistance in multiple genetic backgrounds, including homologous recombination (HR) -proficient cells. RTx-152 selectively kills BRCA2-null cells[1].

• UNSPSC :

  12352005

• Target :

  DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rtx-152.html

• Purity :

  99.71

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  FC(F)(F)C1=CC(N2CCN(C)C2=O)=C(OC(N(C3=CC=C(F)C=C3)C)=O)C(C(F)(F)F)=C1

• Molecular Formula :

  C20H16F7N3O3

• Molecular Weight :

  479.35

• References & Citations :

  [1]Fried W, et al. Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors. Nat Commun. 2024 Apr 5;15 (1) :2862.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3035072-48-8]