I-152

• Description :

  I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA) . I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties[1].

• UNSPSC :

  12352211

• Target :

  Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/i-152.html

• Purity :

  98.78

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(SCCNC([C@H](CS)NC(C)=O)=O)=O

• Molecular Formula :

  C9H16N2O3S2

• Molecular Weight :

  264.36

• References & Citations :

  [1]Crinelli R, et al. Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine. Antioxidants (Basel) . 2021 Jan 26;10 (2) :175.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [311343-11-0]