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Difopein (TFA)

CAT: 0804-HY-P1380A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1380A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Difopein TFA, a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein TFA is not cell permeable. Difopein TFA leads to induction of apoptosis and enhances the ability of Cisplatin to kill cells[1][2].
UNSPSC
12352209
Target
Apoptosis
Type
Peptides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/difopein-tfa.html
Purity
96.30
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
[SADGAPHCVPRDLSWLDLEANMCLPGAAGLDSADGAPHCVPRDLSWLDLEANMCLPGAAGLE(TFAsalt)]
Molecular Formula
C273H424N76O89S6.xC2HF3O2
Molecular Weight
6387.17 (free acid)
References & Citations
[1]Masters SC, et al. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001 Nov 30;276 (48) :45193-200. Epub 2001 Sep 27.|[2]Peluso JJ, et al. Progesterone regulates granulosa cell viability through a protein kinase G-dependent mechanism that may involve 14-3-3sigma. Biol Reprod. 2004 Dec;71 (6) :1870-8.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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