LY2979165 (free base)

• UNSPSC Description:

  LY2979165 free base is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1].

• Target Antigen:

  mGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ly2979165-free-base.html

• Smiles:

  [H][C@]12[C@](C(O)=O)(C[C@H]([C@]1([C@@H]2C(O)=O)[H])SC3=NN=CN3)NC([C@H](C)N)=O

• Molecular Weight:

  355.37

• References & Citations:

  [1]Juliet McColm , et al. Evaluation of Single and Multiple Doses of a Novel mGlu2 Agonist, a Potential Antipsychotic Therapy, in Healthy Subjects. Br J Clin Pharmacol. 2017 Aug;83(8):1654-1667.|[2]Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl). 2018 Jul;235(7):1875-1886.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  1311385-35-9