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Masupirdine (free base)

CAT: 0804-HY-109118Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-109118Size:1 Each
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Description
Masupirdine free base (SUVN-502 free base) is a potent, selective, orally active, and brain-penetrating 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine free base has pro-cognitive effects on all stages of cognition (acquisition, consolidation, and retention), and can reverse Scopolamine , MK-801 (HY-15084B) -induced and aging-related memory deficits. Masupirdine free base can be used in the research of Alzheimer's disease[1][2].
CAS Number
701205-60-9
Product Name Alternative
SUVN-502 (free base)
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/masupirdine-free-base.html
Solubility
10 mM in DMSO
Smiles
O=S(N1C2=CC=C(OC)C=C2C(CN3CCN(C)CC3)=C1)(C(C=CC=C4)=C4Br)=O
Molecular Formula
C21H24BrN3O3S
Molecular Weight
478.40
References & Citations
[1]Nirogi R, et al. Discovery and Development of 1-[ (2-Bromophenyl) sulfonyl]-5-methoxy-3-[ (4-methyl-1-piperazinyl) methyl]-1H-indole Dimesylate Monohydrate (SUVN-502) : A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease. J Med Chem. 2017 Mar 9;60 (5) :1843-1859.|[2]Nirogi R, et al. SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization. Behav Pharmacol. 2019 Feb;30 (1) :16-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT2 Receptor;5-HT6 Receptor; MUC2

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