LY2979165

• Description:

  LY2979165 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/LY2979165.html

• Purity:

  99.30

• Solubility:

  DMSO : < 1 mg/mL|H2O : ≥ 50 mg/mL

• Smiles:

  [H][C@]12[C@](C(O)=O)(C[C@H]([C@]1([C@@H]2C(O)=O)[H])SC3=NN=CN3)NC([C@H](C)N)=O.N.O

• Molecular Formula:

  C13H22N6O6S

• Molecular Weight:

  390.42

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Juliet McColm , et al. Evaluation of Single and Multiple Doses of a Novel mGlu2 Agonist, a Potential Antipsychotic Therapy, in Healthy Subjects. Br J Clin Pharmacol. 2017 Aug;83 (8) :1654-1667.|[2]Mitul A Mehta, et al. Group II metabotropic glutamate receptor agonist prodrugs LY2979165 and LY2140023 attenuate the functional imaging response to ketamine in healthy subjects. Psychopharmacology (Berl) . 2018 Jul;235 (7) :1875-1886.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  MGluR2

• CAS Number:

  1311385-32-6