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ATC0175 (free base)

CAT: 0804-HY-116031Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116031Size:1 Each
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Description
ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC50 value of 3.4 nM, as well as good selectivity over the Y5 and the α2A receptors. ATC0175 (free base) is promising for research of obesity[1].
CAS Number
509118-03-0
UNSPSC
12352005
Target
MCHR1 (GPR24)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/atc0175-free-base.html
Smiles
CN(C1=NC(N[C@H]2CC[C@H](CC2)NC(C3=CC(F)=C(C=C3)F)=O)=NC4=C1C=CC=C4)C
Molecular Formula
C23H25F2N5O
Molecular Weight
425.47
References & Citations
[1]Kanuma K, et al. Lead optimization of 4- (dimethylamino) quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett. 2005 Sep 1;15 (17) :3853-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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