Usmarapride (free base)

CAT: 0804-HY-116565A-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-116565A-01Size:5 mg

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Description

Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM) . Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer's disease[1].

CAS Number

1428862-32-1

Product Name Alternative

SUVN-D4010 (free base)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/usmarapride-free-base.html

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL

Smiles

CC(N1N=C(C2=NN=C(C3CCN(CCCOC)CC3)O2)C4=C1C=CC=C4)C

Molecular Formula

C21H29N5O2

Molecular Weight

383.49

References & Citations

[1]Nirogi R, et al. Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010) : A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease. J Med Chem. 2021;64 (15) :10641-10665.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

Apolipoprotein D

Chemical Information

Suvn-d4010

Usmarapride is a small molecule drug. The usage of the INN stem '-pride' in the name indicates that Usmarapride is a sulpiride derivative and analogue. Usmarapride has a monoisotopic molecular weight of 383.23 Da.

CAS Number	1428862-32-1
PubChem CID	71508291
IUPAC Name	2-[1-(3-methoxypropyl)piperidin-4-yl]-5-(1-propan-2-ylindazol-3-yl)-1,3,4-oxadiazole
Molecular Formula	C21H29N5O2
Molecular Weight	383.5
XLogP	2.6
Topological Polar Surface Area	69.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Heavy Atom Count	28
Formal Charge	0
Complexity	485

SMILES

CC(C)N1C2=CC=CC=C2C(=N1)C3=NN=C(O3)C4CCN(CC4)CCCOC

InChI

InChI=1S/C21H29N5O2/c1-15(2)26-18-8-5-4-7-17(18)19(24-26)21-23-22-20(28-21)16-9-12-25(13-10-16)11-6-14-27-3/h4-5,7-8,15-16H,6,9-14H2,1-3H3

InChIKey

DWTFBJGTRBMHPG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1428862-32-1

CID: 71508291

Formula: C21H29N5O2

MW: 383.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	383.5
XLogP3	2.6
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	383.23212518
Monoisotopic Mass	383.23212518
Topological Polar Surface Area	69.2 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	485
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Usmarapride (free base)

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