FOSL1 degrader 1

• UNSPSC Description:

  FOSL1 degrader 1 (4) is a T-5224-PROTAC, potently degrade FOSL1 (AP-1) to suppress cancer stemness gene expression in HNSCC. FOSL1 degrader 1 (4) effectively eliminate HNSCC cancer stem cells to inhibit tumor growth through degrading FOSL1. FOSL1 degrader 1 (4) displays around 30- to 100-fold increased potency over T-5224 (Pink: T-5224 (HY-12270); Black: Linker (HY-130200); Blue: Pomalidomide (HY-10984))[1].

• Target Antigen:

  AP-1; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fosl1-degrader-1.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C1CCC(N2C(C(C(NCCOCCOCCOCCOCCOCCOCCOCCNC(CCC3=C(OCC4=CC(ON=C5O)=C5C=C4)C=CC(C(C6=C(O)C=C(OC7CCCC7)C=C6)=O)=C3)=O)=CC=C8)=C8C2=O)=O)C(N1)=O

• Molecular Weight:

  1124.19

• References & Citations:

  [1]Shadid U Zaman, et al. Novel PROTAC probes targeting FOSL1 degradation to eliminate head and neck squamous cell carcinoma cancer stem cells. Bioorg Chem. 2024 Jul 9:151:107613.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported