Tyk2-IN-9

• Description:

  Tyk2-IN-9 (Compound 26) is a selective Tyk-2 inhibitor with IC50s of 0.076 and 1.8 nM for TYK2-JH2 and JAK1-JH2, respectively. Tyk2-IN-9 can be used for the research of inflammatory or autoimmune disease[1].

• UNSPSC:

  12352005

• Target:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tyk2-in-9-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=NN4C=C(N5CC(C(C)O)C5)C=CC4=N3)NC

• Molecular Formula:

  C21H25N9O3

• Molecular Weight:

  451.48

• References & Citations:

  [1]Qiuwen WANG, et al. Tyk-2 inhibitor. WO2021170046A1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2694816-85-6]