Tyk2-IN-9

• Description :

  Tyk2-IN-9 (Compound 26) is a selective Tyk-2 inhibitor with IC50s of 0.076 and 1.8 nM for TYK2-JH2 and JAK1-JH2, respectively. Tyk2-IN-9 can be used for the research of inflammatory or autoimmune disease[1].

• UNSPSC :

  12352005

• Target :

  JAK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/tyk2-in-9-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=NN=C(NC(C2CC2)=O)C=C1NC3=NN4C=C(N5CC(C(C)O)C5)C=CC4=N3)NC

• Molecular Formula :

  C21H25N9O3

• Molecular Weight :

  451.48

• References & Citations :

  [1]Qiuwen WANG, et al. Tyk-2 inhibitor. WO2021170046A1.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2694816-85-6]