Tyk2-IN-22

• Target:

  JAK

• Related Pathways:

  Angiogenesis|||Tyrosine Kinase/Adaptors|||Stem Cells|||JAK/STAT signaling|||Chromatin/Epigenetic

• Bioactivity:

  Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.

• Smiles:

  O=C1C=C (N=C2NC (=NN12) C=3C=CC (Cl) =CC3) CN4CCOCC4

• Molecular Formula:

  C16H16ClN5O2

• Molecular Weight:

  345.78

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  933667-23-3