Tyk2-IN-22

• Target :

  JAK

• Related Pathways :

  Angiogenesis|||Tyrosine Kinase/Adaptors|||Stem Cells|||JAK/STAT signaling|||Chromatin/Epigenetic

• Bioactivity :

  Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.

• Smiles :

  O=C1C=C(N=C2NC(=NN12)C=3C=CC(Cl)=CC3)CN4CCOCC4

• Molecular Formula :

  C16H16ClN5O2

• Molecular Weight :

  345.78

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  933667-23-3