Xanthopterin (hydrate)

• Description:

  Xanthopterin hydrate, an unconjugated pteridine compound, is the main component of the yellow granule in the Oriental hornet bear wings, produces a characteristic excitation/emission maximum at 386/456 nm[2]. Xanthopterin hydrate (XPT) causes renal growth and hypertrophy in rat[1]. Xanthopterin hydrate inhibits RNA synthesis[4].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H320, H335

• Target:

  DNA/RNA Synthesis

• Type:

  Natural Products

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/xanthopterin-hydrate.html

• Purity:

  98.0

• Solubility:

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  O=C1NC(N)=NC2=C1NC(C=N2)=O.O

• Molecular Formula:

  C6H7N5O3

• Molecular Weight:

  197.15

• Precautions:

  H302, H315, H320, H335

• References & Citations:

  [1]Xanthopterin (XPT), an unconjugated pteridine compound, affects cell growth and differentiation. When injected into rats, XPT has caused changes that have been interpreted as renal growth and hypertrophy.|[2]Lord JL, et al. Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. Cancer Lett. 2005 May 10;222 (1) :119-24.|[3]Plotkin M, et al. Xanthopterin in the Oriental hornet (Vespa orientalis) : light absorbance is increased with maturation of yellow pigment granules. Photochem Photobiol. 2009 Jul-Aug;85 (4) :955-61.|[4]Ziegler I, et al. Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. Hoppe Seylers Z Physiol Chem. 1984 Jun;365 (6) :667-73.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  5979-01-1